Clinical Trial in Patients

With IBS Diarrhoea

RELIEVE IBS-D: “Enterosgel in the treatment of Irritable Bowel Syndrome with Diarrhoea (IBS-D) in adults”.

In this large randomized clinical trial set in 28 GP and hospital sites in England and a “virtual site”, we recruited 440 patients with IBS-D. Patients received either Enterosgel® or placebo for 8-weeks, then both groups received Enterosgel® for a further 8-weeks.

The study results showed that significantly more patients that took Enterosgel compared to placebo showed a reduction in diarrhoea, abdominal pain, bloating, stool frequency and urgency. More Enterosgel patients also showed improvement in their “quality of life” score and adequate relief of their symptoms.

Enterosgel is a safe and effective treatment of IBS-D and could improve patients’ quality of life.

Prof Yan Yiannakou
Chief Investigator of IBS-D study

“this study showed that 74% of patients that took Enterosgel reported adequate relief of their IBS symptoms. Enterosgel is an effective treatment option for patients with IBS-D”

Clinical Trial in Patients

With Acute Diarrhoea

A 2019 randomised controlled clinical study investigating Enterosgel use in acute diarrhoea, recruited 105 patients from ten GP surgeries across England. Patients were randomised to the treatment group which received Enterosgel and oral rehydration solution for 8 days, or the control group which received oral rehydration solution alone. 

The study results showed that the duration of diarrhoea was significantly shorter in the Enterosgel group at 27 hours compared to 39 hours in the control group. Enterosgel was also shown to be well-tolerated and safe.

Study conclusion

Enterosgel treatment led to a significant reduction in the duration of diarrhoea in adults with acute diarrhoea, compared with standard care alone.

These findings support previous Enterosgel studies in children with acute diarrhoea and show that Enterosgel is a safe and effective treatment for short-term diarrhoea and can reduce diarrhoea symptoms in all age groups.

Dr Preeti Pandya
Chief Investigator of IBS-D study

“this study showed that Enterosgel can reduce the duration of acute diarrhoea and relieve associated symptoms, and is one of the few safe treatment options currently available for children”