ENTEROSGEL® is an oral intestinal adsorbent (enterosorbent).
It is based on a mineral (organosilicon compound: polymethylsiloxane polyhydrate) with adsorption capacity towards some toxic and harmful substances in the gut (e.g. endotoxins, enterotoxins), physically binding them to its surface, with the intention of reducing stool frequency and duration of diarrhoea.
ENTEROSGEL® has several unique features
Both hydrophilic (-OH) and hydrophobic (-CH3) surface groups, so can adsorb both hydrophobic and hydrophilic molecules.
A hydrogel with a unique porous structure consisting of small micropores and a majority of larger mesopores suitable for adsorption of toxins.
These properties favour ENTEROSGEL’S® adsorption of toxins and limit adsorption of lower molecular mass solutes such as pharmaceutical drugs.
ENTEROSGEL® is a drug free alternative that has been very widely used in many countries, with no reports of adverse effects. Its safety and performance has been confirmed in numerous clinical investigations with over three thousand patients treated with ENTEROSGEL®. These studies have shown reductions in blood endotoxin levels resulting from treatment with ENTEROSGEL® and a statistically significant reduction, from 6.1 to 4.5 days, in the duration of diarrhoea for ENTEROSGEL® (n=146), compared with other treatments (n= 195). When used to treat chronic diarrhoea associated with irritable bowel syndrome, ENTEROSGEL® has been shown to lead to normalisation of stool frequency and decrease of abdominal pain.
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